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From providing a viable way to the weight problems pandemic and its comorbidities to lowering the call for for ResMed’s steady Sure Airway Drive (PAP) treatment units which are used to regard the indicators of sleep apnea, it’s hardly ever unexpected that GLP-1 medicine lately represent one in all Wall Side road’s greatest thematic funding concepts for the continuing decade. Even so, researchers proceed to find new use-cases for those miracle medicine, with the most recent such discovery centering on alcohol dependancy keep watch over.
A Primer On GLP-1 Medication
The GLP-1 hormone suppresses starvation and regulates the manufacturing of insulin and glucose. After a meal, this hormone raises the extent of insulin, which decreases blood glucose ranges. Concurrently, it reduces the speed at which the tummy empties its contents into the small gut, growing a sense of fullness and satiation within the procedure. Whilst to start with billed as a remedy for diabetes, most of the medicine that make the most of GLP-1 agonists are actually bought as a devoted anti-obesity palliative choice.
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Estimated international weight reduction drug gross sales:
2030: $93.8 billion
2029: $77.9 billion
2028: $63.7 billion
2027: $48.6 billion
2026: $35.4 billion
2025: $24.6 billion
2024: $14.8 billion
2023: $6.3 billion
Supply: Bloomberg Intelligence
— Jon Erlichman (@JonErlichman) June 22, 2024
Novo Nordisk makes use of semaglutide as its proprietary GLP-1 agonist in medicine which are advertised beneath Ozempic and Wegovy labels, with the previous aimed at type-2 diabetes and the latter advertised as a remedy for weight problems.
Whilst Novo Nordisk lately has quite a lot of further GLP-1 medicine within the pipeline, together with the ones that may be ingested and people who leverage each GLP-1 and Amylin agonists to supply higher efficacy, Wegovy and Ozempic stay the corporate’s number one choices for now to regard weight problems and diabetes.
New Find out about: The Semaglutide GLP-1 Agonist Can Considerably Cut back Alcohol Consumption
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1/ GLP-1s WILL HELP YOU KICK ALCOHOL! 🍻
(If you’re a vervet monkey 🐒….for now)
Impact of the glucagon-like peptide-1 (GLP-1) receptor agonist semaglutide on alcohol intake in alcohol-preferring male vervet monkeys
Reasonable day by day alcohol consumption (g/kg/4 hours) at week 6,… %.twitter.com/cNHcZl5fmO
— BowTiedBiotech 🧪🔬🧬 (@BowTiedBiotech) June 22, 2024
This brings us to the crux of the topic. Given the certain results of the GLP-1 agonists in lowering nicotine dependancy, a bunch of researcher not too long ago attempted to analyze the hormone’s effectiveness in controlling alcohol intake.
The researchers injected a randomized crew of male vervet monkeys with both “escalating doses” (as much as 0.05 mg/kg) of the semaglutide GLP-1 agonist or a placebo two times weekly for 2 weeks. Whilst the monkey had get admission to to alcohol for 10 days previous to the beginning of the remedy, no alcohol used to be to be had all the way through those two weeks of remedy. Thereafter, over the next 20 running days, researchers re-introduced alcohol whilst proceeding the two times weekly management of semaglutide and the placebo.
The GLP-1 agonist Semaglutide used to be ready to inspire a bunch of monkeys to drink extra water versus alcohol
In keeping with the result of this learn about, semaglutide-treated monkeys drank considerably much less alcohol compared to the keep watch over crew following the learn about’s two-week alcohol drought length.
After all, this learn about handiest keen on our mammalian cousins and the GLP-1 agonists is probably not as efficient in controlling alcohol dependancy in people. It does, on the other hand, open a brand new vector for researchers to discover.
