Disbursed prescription stimulants amongst US adults elderly 64 years and more youthful. Credit score: JAMA Psychiatry (2025). DOI: 10.1001/jamapsychiatry.2025.0054
Analysis carried out through the Nationwide Institute on Drug Abuse, the Substance Abuse and Psychological Well being Services and products Management, and the Facilities for Illness Regulate and Prevention finds that 1 in 4 adults the usage of prescription stimulants engaged in misuse, and just about 1 in 10 met the standards for prescription stimulant use dysfunction (PSUD).
Findings display that amphetamine customers had been much more likely to revel in PSUD than the ones prescribed methylphenidate. Larger prescribing charges, in particular amongst middle-aged ladies, had been seen, but this demographic exhibited decrease misuse charges than more youthful adults.
Considerations over stimulant misuse have grown as prescribing charges for those medicines, repeatedly used to regard attention-deficit/hyperactivity dysfunction (ADHD), have greater. Medical apply tips for grownup ADHD stay absent, resulting in diversifications in prognosis and remedy. Questions on suitable use persist as analysis signifies each the protecting advantages of ADHD pharmacotherapy and its possible dangers, together with misuse, overprescription, and construction of use issues.
Within the learn about, “Prescription Stimulant Use, Misuse, and Use Dysfunction Amongst US Adults Elderly 18 to 64 Years,” printed in JAMA Psychiatry, researchers carried out a cross-sectional survey learn about to know patterns of prescription stimulant use and misuse amongst adults.
Stimulant prescribing traits from 2019 via 2022 had been tested the usage of pharmaceutical databases that captured 93% of outpatient prescriptions disbursed in U.S. retail pharmacies. Further information on stimulant misuse, PSUD incidence, and related behavioral well being stipulations had been drawn from the NSDUH survey effects. Survey responses from 83,762 adults elderly 18 to 64 years had been analyzed.
A, Proportions of people with and with out prescription stimulant misuse general and through PSUD severity. B, Proportions of PSUD through prescription stimulant medicine sort. Credit score: JAMA Psychiatry (2025). DOI: 10.1001/jamapsychiatry.2025.0054
Effects point out that 25.3% of adults the usage of prescription stimulants reported misuse, with 9.0% assembly the standards for PSUD. Amongst the ones with PSUD, 72.9% used handiest their very own prescribed stimulants, and 87.1% had been prescribed amphetamines. Research printed that amphetamine customers had been 3.1 instances much more likely to misuse their medicine than the ones prescribed methylphenidate, with a 2.2 instances higher chance of creating PSUD.
Prescriptions for stimulants greater throughout all demographics, with essentially the most considerable upward thrust happening amongst ladies elderly 35 to 64 years. Misuse of prescription stimulants used to be extra not unusual amongst people with despair, suicidal ideation, or concurrent substance use issues. Girls elderly 35 to 64 years exhibited a decrease incidence of misuse than more youthful adults, with charges of 13.7% in comparison to 36.8% amongst ladies elderly 18 to twenty-five years.
In line with the learn about authors, “Our effects underscore the significance of creating and enforcing scientific apply tips for grownup ADHD and strengthening evidence-based clinician coaching techniques on grownup ADHD prognosis and multimodal care. Additionally, our findings spotlight the desire for prevention and intervention of prescription stimulant misuse, diversion, or PSUD without reference to misuse standing and the explanations for prescribing stimulants.”
Additional info:
Beth Han et al, Prescription Stimulant Use, Misuse, and Use Dysfunction Amongst US Adults Elderly 18 to 64 Years, JAMA Psychiatry (2025). DOI: 10.1001/jamapsychiatry.2025.0054
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