It is being hailed as the largest leap forward since statins – no less than that is how some professionals are heralding the newest discovering concerning the weight-loss ‘marvel drug’ Ozempic.Administered as a as soon as per week homemade injection – a lot favoured through celebrities together with Oprah Winfrey and pa superstar Boy George – Ozempic has already earned an impressive recognition as a remedy for weight problems, because of its key aspect, semaglutide.That is the drug in each Ozempic (which is authorized to be used in kind 2 diabetes in the United Kingdom) and Wegovy (most often a reasonably upper dose however authorized right here just for weight reduction).It really works through mimicking the consequences of a hormone known as glucagon-like peptide-1 (GLP-1), which is launched through the intestine when we devour, to ship a message to the mind that we’re complete. Tv sensation Oprah Winfrey has trimmed down in recent times because of OzempicSemaglutide turns on GLP-1 receptors within the mind which check in fullness within the abdomen after minimum quantities of meals. In consequence, folks really feel complete after even small quantities of meals.And because shedding pounds is likely one of the most efficient tactics of keeping off middle assaults and strokes, the well being advantages had been already glaring.However what is in point of fact stuck the eye and made headlines international these days is new proof that the drug dramatically reduces the possibilities of middle illness – through 20 in keeping with cent – even supposing sufferers do not essentially drop some weight whilst on it.It means that Ozempic and different medicine in the similar magnificence can have an immediate and certain impact at the middle – become independent from weight reduction – which at the face of it will lift it to tremendous drug standing.Upload to that the rising proof that the similar medicine may additionally be efficient towards different killer stipulations reminiscent of most cancers, Alzheimer’s, Parkinson’s illness or even more than one sclerosis (MS), and it begs the query – can we all finally end up on them in the end?Sir John Bell, former Regius Professor of Medication at Oxford College, instructed BBC Radio 4’s Global at One: ‘ That is the start of the evolution of those medicine the place they’ll develop into like statins, the place a lot of people take them and would possibly keep on them for a very long time.’It is a primary second in scientific science – however is it in point of fact as essential a leap forward because it sounds, or is it being overhyped? Right here we give you the solutions to a lot of these a very powerful questions and extra.Q: Why is that this newest analysis inflicting such pleasure?Since the SELECT learn about, led through researchers from College School London, is the biggest ever investigation into the cardiac advantages of semaglutide – and the scientists had been very stunned to look the medicine labored even if sufferers did not drop some weight.The analysis concerned 17,604 adults elderly over 45 with a prime frame mass index (BMI, a measure of weight in comparison to peak) and had suffered a prior cardiac ‘match’ – reminiscent of a middle assault. 
Sharon Osbourne has spoken brazenly about the use of Ozempic to narrow down after pronouncing she had struggled together with her weight for lots of yearsFor just about 4 years, they both had a weekly 2.5mg shot of semaglutide (the upper dose utilized in Wegovy jabs – the quantity in Ozempic is most often so much decrease), or a placebo jab.The consequences, introduced at a big weight problems convention in Venice previous this week, confirmed that out of the 8,803 sufferers at the placebo jab, 701 (or 8 in keeping with cent) suffered a middle assault. However within the semaglutide workforce it used to be simplest 569 (or 6.5 in keeping with cent).Crucially, the autumn in middle possibility used to be noticed even in those that hadn’t but misplaced a large number of weight. And middle assault and stroke charges began to drop inside of weeks of beginning the GLP-1 medicine.In truth, the autumn in possibility used to be identical in those that misplaced not up to 5 in keeping with cent in their body weight – and even placed on a couple of kilos – because it used to be in those that shed over 5 in keeping with cent.(And this used to be sooner than maximum sufferers reached their most weight reduction, which used to be a 12 months or so into remedy.)’That is tremendous attention-grabbing,’ says Dr Alex Miras, scientific professor of drugs at Ulster College and a professional in weight problems remedy.’We didn’t know this sooner than – it can be the drug is having an immediate impact at the middle, unbiased of weight reduction.’One clarification could also be that the jab reduces the type of continual, low-level irritation in blood vessels that may lead them to develop into blocked – resulting in a middle assault or stroke.’However there may be additionally proof that the GLP-1 hormone has one of those anti-clotting impact and that’s the reason very thrilling,’ says Dr Miras.Q: So must all of us be on it?If semaglutide can cut back middle illness possibility even if patents on it do not lose plenty of weight, must thousands and thousands extra people be taking it to stay our hearts wholesome – simply as we do with statins?’No,’ says Dr Miras. ‘Research up to now simplest display that the drug is efficacious in people who find themselves already overweight and now have established middle illness – they have got both had a middle assault, a stroke or a clot within the blood vessels within the legs.’From what we all know, semaglutide is not likely to paintings as smartly in the principle prevention of middle illness’. That is the place sufferers have possibility components, reminiscent of a circle of relatives historical past or prime ldl cholesterol, however have now not in fact suffered a middle assault or stroke.’The drug has a miles better impact in the ones with current middle illness.’It is imaginable that may alternate as we be informed extra.Dr Miras provides: ‘It is imaginable that 10 years down the road you could be given the medicine if in case you have a powerful circle of relatives historical past of middle illness however there is not any proof base for that but.’Q: Is it true it may possibly lend a hand save you different stipulations like Alzheimer’s?Weight-loss and middle issues apart, some proof is rising to indicate Ozempic and identical drugs may just probably take on different modern day killers.Those vary from bowel most cancers and Alzheimer’s illness to more than one sclerosis and Parkinson’s illness.A 3-year trial is already underway at quite a lot of centres throughout the United Kingdom to look if folks with delicate cognitive impairment – usally an early degree of Alzheimer’s – will have the benefit of taking a day-to-day semaglutide pill.Once more, irritation is understood to play an element within the development of Alzheimer’s, elevating the chance of destructive deposits – known as plaques – forming within the mind. The idea is that the drug given early sufficient will prevent additional plaques from forming.In the meantime, a December 2023 learn about in JAMA Oncology discovered that kind 2 diabetes sufferers given semaglutide had a 44 in keeping with cent fall within the possibility of bowel most cancers (most certainly on account of its anti inflammatory results) whilst closing month scientists at Toulouse College Health facility in France reported a day-to-day injection of semaglutide slowed the development of Parkinson’s illness.’We have now identified for years from animal fashions that semaglutide has anti inflammatory results,’ says Dr Miras.’However the GLP-1 hormone additionally turns out to offer protection to towards harm to nerve cells’ – the type of harm noticed in Parkinson’s and MS. 
Sharon’s daughter Kelly Osbourne has extensively utilized the weight-loss drug, however shared that she felt it had long gone ‘too a long way’Q: Is it true Ozempic can prevent you consuming?One of the crucial many various results of the drug appears to be that it may possibly curb the need to drink alcohol.A 2023 learn about at Gothenburg College in Sweden discovered that rats given the drug fed on 60 in keeping with cent not up to the ones now not injected with semaglutide.Equivalent analysis is underway at Oklahoma State College, involving 80 heavy drinkers, to look what impact weekly injections of the drug have over a three-month length.It is not transparent why the drug would possibly make alcohol much less interesting however one idea is it dampens down the ‘praise’ hit that the mind will get when alcohol is fed on – decreasing the urge to stay consuming.Q: What about side-effects?Like any prescription drugs, semaglutide will have ugly penalties.As an example, research display round one in 100 folks broaden gastroparesis (or abdomen paralysis) the place the tummy muscle tissues develop into weakened or may also be paralysed, that means meals strikes throughout the digestive machine a lot slower than customary and in some circumstances it would possibly not transfer in any respect. It will purpose nausea, ache and bloating and it’s been claimed in a single report back to cause cyclic vomiting syndrome, the place folks vomit a number of occasions an afternoon.Round part those that broaden gastroparesis additionally develop into constipated which is able to closing six weeks or extra.It could possibly additionally purpose serious diarrhoea – some sufferers record soiling the mattress at night time.Some additionally whinge of foul-smelling ‘rotten egg’ burps. It can be since the drug will increase the choice of sulphur-producing micro organism within the intestine, through changing the microbiome (the neighborhood of micro organism, viruses and different microbes that are living there). Every other idea is that as it slows the gastric-emptying procedure, meals lingers for longer than customary – inflicting extra ugly aromas.Then there may be so-called ‘Ozempic face’, an often-reported side-effect the place sped up facial growing older – extra wrinkles and baggy pores and skin – develops after a couple of months at the drug.It is idea that is because of the fast weight reduction resulting in a discount in facial fats; when it disappears, the surface can seem to be saggier.Possibly extra being concerned is the instructed hyperlink with suicidal ideas.Newest figures from the Medications and Healthcare merchandise Regulatory Company – the frame that vets drug protection in the United Kingdom – display it has gained over 100 reviews since 2019 linking semaglutide with despair and 38 circumstances the place it has allegedly brought about suicidal ideas.In a single case, the drug has been blamed for a affected person committing suicide.Then again, it is not transparent if the drug used to be in fact accountable and a learn about printed in magazine Nature previous this 12 months through professionals at Case Western Reserve College of Medication, which regarded on the data of one.8million folks at the medicine, discovered no proof of a hyperlink with suicidal ideas. 
Kelly Clarkson attributed her weight-loss to a prescription drug that helped her frame damage down sugar, however mentioned it wasn’t OzempicQ. What are the long-term dangers?Some sufferers on Ozempic for his or her kind 2 diabetes for have reported vital side-effects reminiscent of pancreatitis (irritation of the pancreas), kidney failure, gall bladder irritation or even imaginative and prescient issues whilst taking the drug.And even if the drop-out charge all over scientific trials run through the drug’s producers used to be simplest round 8 in keeping with cent of sufferers, a learn about within the BMJ in 2022 – which checked out 589 Britons who have been prescribed GLP-1 medicines for kind 2 diabetes – confirmed the drop-out charges in actual lifestyles had been 45 in keeping with cent after 12 months and 65 in keeping with cent at two years.However, Sir John Bell says: ‘Those medicine had been used for the remedy of diabetes for greater than 15 years and we’ve a large number of revel in with them – there may be moderately a large database on their protection they usually paintings beautiful smartly.’Q: I am tempted however how can I am getting the jab?Wegovy (the load loss model) is simplest to be had at the NHS if in case you have a BMI of no less than 35. As a coarse instance, this is usually a guy who’s 5ft 10in tall and weighs nearly 18 stone. In outstanding cases, you can get it if in case you have a BMI of 30 (eg: a 5ft 3in lady who’s 12 stone) however most often simplest if in case you have a variety of different possibility components basically for middle illness or stroke – reminiscent of hypertension.It is usually to be had privately from on-line pharmacies, beginning at round £150 a month, however you’ll desire a non-public prescription from a physician first.However be warned – you’ll be able to recently simplest keep at the drug for 2 years – as the pains upon which the drug’s approval had been primarily based simplest lasted two years. The SELECT learn about lasted 4 so now there are requires this to be prolonged and the general public regain no less than one of the weight after they hand over.Q: However is not Ozempic briefly provide?Some on-line pharmacies say they can’t tackle new sufferers for Ozempic for a number of months because of long-running shortages of the drug. As an alternative, they’re having to order the provides they do have for current sufferers. The charity Diabetes UK warned not too long ago the availability problems are anticipated to run into 2025 and a few new sufferers are suffering to get their medicine in spite of being prescribed it.Diabetes UK blamed the prime point of ‘off label’ prescribing of the medicine Ozempic to these non-public sufferers determined to make use of them for weight reduction.Q: I hate injections – can I am getting a pill as a substitute?Semaglutide is already to be had in the United Kingdom as a tablet known as Rybelsus. However it is just to be had on prescription for folks with diabetes, now not for weight reduction, and in a miles upper dose than the weekly jab (50mg as opposed to simply 2.4mg within the injection). That is as a result of taking it orally method a lot of the energetic drugs will get ‘misplaced’ or destroyed through abdomen acid on its adventure throughout the intestine, sooner than after all being absorbed into the bloodstream. With an injection, just about all the energetic aspect is assured to be absorbed into the bloodstream after which flow into to the mind.Sir John Bell says: ‘There are a chain of oral medicine coming thru which can be going to be a lot less expensive than the injected shape.’
